Multiple comparisons in long-term toxicity studies.
نویسندگان
چکیده
منابع مشابه
Multiple comparisons in long-term toxicity studies.
Several multiple comparison procedures (MCPs) are discussed in relation to the specific formulation of type I and type II errors in toxicity studies and the typical one-way design control versus k treatment/dose groups. Examples for these MCPs are: the standard many-to-one MCP (Dunnett's procedure), sequential rejection modifications, closed testing procedures, many-to-one MCPs with an ordered ...
متن کاملLong-term clinical toxicity studies with clofazimine (B663) in leprosy.
Fifty-one leprosy patients receiving long-term clofazimine have undergone systematic clinical laboratory testing in a search for any toxicity secondary to the drug. In approximately 220 patient-years of observation and in analyzing approximately 40,000 test results, no statistically significant changes in the direction of abnormality have been observed in SGOT, thymol turbidity, serum globulins...
متن کاملLong-term toxicity studies on Chocolate Brown HT in rats.
Groups of 48 males and 48 female rats were given diets containing 0 (control), 500, 2000 or 10,000 ppm Chocolate Brown HT for 2 years. These treatments had no adverse effect on mortality, body-weight gain, food or water consumption, haematology, renal function, serum constituents, organ weight or histopathology. From the incidence of tumours observed in the control and test animals it is conclu...
متن کاملPreclinical rodent toxicity studies for long term use of ceftriaxone
A 6-month rodent toxicology and pharmacokinetic (PK) study was performed to provide supportive safety data for long-term use of intravenous ceftriaxone in a clinical trial in patients with amyotrophic lateral sclerosis (ALS). Ceftriaxone was administered by subcutaneous injection at up to 2 g/kg/day to Sprague-Dawley Crl:CD (SD) rats. Ceftriaxone was found to be safe and well tolerated. Specifi...
متن کاملRetinal toxicity in long term hydroxychloroquine treatment.
OBJECTIVE To report clinical experience from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) who were receiving recommended doses of hydroxychloroquine for more than six years, and were monitored for evidence of hydroxychloroquine related retinopathy every six months. METHODS A prospective (and continuing) evaluation was made of the potential retinal toxicity of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1994
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.94102s133